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Publications

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2017

Bioengineering strategies for inducing tolerance in autoimmune diabetes.
Baekkeskov S, Hubbell JA, Phelps EA
Advanced Drug Delivery Reviews.2017 Jun 15;pii: S0169-409X(17)30091-1. doi: 10.1016/j.addr.2017.06.007.

Advances in pancreatic islet monolayer culture on glass surfaces enable super-resolution microscopy and insights into beta cell ciliogenesis and proliferation.
Phelps EA*, Cianciaruso C*, Santo-Domingo J, Pasquier M, Galliverti G, Piemonti L, Berishvili E, Burri O, Wiederkehr A, Hubbell JA, Baekkeskov S. *Equal Contribution.
Scientific Reports. 2017 Apr 12;7:45961. doi: 10.1038/srep45961.

Vaccine nanocarriers: Coupling intracellular pathways and cellular biodistribution to control CD4 vs CD8 T cell responses.
Rincon-Restrepo M, Mayer A, Hauert S, Bonner DK, Phelps EA, Hubbell JA, Swartz MA, Hirosue S
Biomaterials.2017 Mar 30;132:48-58. doi: 10.1016/j.biomaterials.2017.03.047.

Primary Human and Rat β-Cells Release the Intracellular Autoantigens GAD65, IA-2, and Proinsulin in Exosomes Together With Cytokine-Induced Enhancers of Immunity.
Cianciaruso C, Phelps EA, Pasquier M, Hamelin R, Demurtas D, Alibashe Ahmed M, Piemonti L, Hirosue S, Swartz MA, De Palma M, Hubbell JA, Baekkeskov S.
Diabetes. 2017 Feb;66(2):460-473. doi: 10.2337/db16-0671.
Front Cover

2016

Aberrant accumulation of the diabetes autoantigen GAD65 in Golgi membranes in conditions of ER stress and autoimmunity.
Phelps EA, Cianciaruso C, Michael IP, Pasquier M, Kanaani J, Nano R, Lavallard V, Billestrup N, Hubbell JA, Baekkeskov S.
Diabetes. 2016 Sep;65(9):2686-99. doi: 10.2337/db16-0180.

2015

Crystalline oligo(ethylene sulfide) domains define highly stable supramolecular block copolymer assemblies.
Brubaker CE, Velluto D, Demurtas D, Phelps EA, Hubbell JA.
ACS Nano. 2015 Jul 28;9(7):6872-81. doi: 10.1021/acsnano.5b02937

Engineered VEGF-releasing PEG-MAL hydrogel for pancreatic islet vascularization.
Phelps EA, Templeman KB, Thule PM, García AJ.
Drug Deliv. Transl. Res. 2015 Apr;5(2):125-36. doi: 10.1007/s13346-013-0142-2
Front Cover, DDTR Outstanding Research Paper Award (Controlled Release Society)

Compartmentalization of GABA synthesis by GAD67 differs between pancreatic beta cells and neurons.
Kanaani J, Cianciaruso C, Phelps EA, Pasquier M, Billestrup N, Baekkeskov S.
PLoS One. 2015 Feb 3;10(2):e0117130. doi: 10.1371/journal.pone.0117130

Light-triggered in vivo activation of adhesive peptides regulates cell adhesion, inflammation and vascularization of biomaterials.
Lee TT, García JR, Paez J, Singh A, Phelps EA, Weis S, Shafiq Z, Shekaran A, del Campo A, García AJ.
Nat. Mater. 2015 Mar;14(3):352-60. doi: 10.1038/NMAT4157
Featured on Front Cover

2013

Cellular encapsulation enhances cardiac repair.
Levit RD, Landazuri N, Phelps EA, Brown ME, García AJ, Davis ME, Giji J, Long R, Safley SA, Suever JD Lyle AN, Weber CJ, Taylor WR.
J. Am. Heart Assoc. 2013 Oct 10;2(5):e000367. doi: 10.1161/JAHA.113.000367

Vasculogenic bio-synthetic hydrogel enhances pancreatic islet engraftment and function in type 1 diabetes.
Phelps EA, Headen DM, Taylor WR, Thule PM, García AJ.
Biomaterials. 2013 Jun;34(19):4602-11. doi: 10.1016/j.biomaterials.2013.03.012.

2012

Dual delivery of hepatocyte and vascular endothelial growth factors via a protease-degradable hydrogel improves cardiac function.
Salimath AS*, Phelps EA*, Boopathy AV; Che P, Brown M, García AJ, Davis ME. *Equal Contribution.
PLoS One. 2012;7(11):e50980. doi: 10.1371/journal.pone.0050980

Maleimide cross-linked bioactive PEG hydrogel exhibits improved reaction kinetics and cross-linking for cell encapsulation and in situ delivery.
Phelps EA, Enemchukwu ND, Fiore VF, Sy JC, Murthy N, Sulchek TA, Barker TH, García AJ.
Adv. Mater. 2012 Jan 3;24(1):64-70, 2. doi: 10.1002/adma.201103574
Inside Front Cover

2011

Effects of protein dose and delivery system on BMP-mediated bone regeneration.
Boerckel JD, Kolambkar YM, Dupont KM, Uhrig BA, Phelps EA, Stevens HY, García AJ, Guldberg RE.
Biomaterials. 2011 Aug;32(22):5241-51. doi: 10.1016/j.biomaterials.2011.03.063

2010

Engineering more than a cell: vascularization strategies in tissue engineering.
Phelps EA, García AJ.
Curr. Opin. Biotechnol. 2010 Oct;21(5):704-9. doi: 10.1016/j.copbio.2010.06.005
Review Article.

Surface functionalization of polyketal microparticles with nitrilotriacetic acid-nickel complexes for efficient protein capture and delivery.
Sy JC, Phelps EA, García AJ, Murthy N, Davis ME.
Biomaterials. 2010 Jun;31(18):4987-94. doi: 10.1016/j.biomaterials.2010.02.063

Bioartificial matrices for therapeutic vascularization.
Phelps EA, Landazuri N, Thule PM, Taylor WR, García AJ.
Proc. Natl. Acad. Sci. U.S.A. 2010 Feb 23;107(8):3323-8. doi: 10.1073/pnas.0905447107