The use of macro-porous scaffolds, made from poly(dimethylsiloxane) (PDMS), is a platform developed in our laboratory to permit retrievability of the scaffold post-transplantation. We have explored the potential of these scaffolds within clinically relevant sites in pre-clinical models. Collectively, these results are promising in that they indicate the potential for transplanting islets into a clinically relevant, extrahepatic site that provides spatial distribution of islets, retrievability, and intra-device vascularization. We are now seeking to translate these promising results to the clinic. With the fabrication of a strong platform for housing cells, particularly islets, we then sought to explore how we may use this platform to interact and instruct the host response.
Learn more about scaffolds and the importance of selecting the appropriate implant site here.
Learn more about scaffolds and the work we are doing to translate them to the clinic here.
Efforts in this area are currently being supported by the JDRF and the Leona M. and Harry S. Helmsley Charitable Trust by projects: “Engineered Bioactive Hydrogel Macrodevices for Islet Transplantation: Engineering an Optimal Site for Islet Transplantation”, a collaborative project with Drs Camillo Ricordi, Luca Inverardi, Rodolfo Alejandro, Alice Tomei, and Dora Berman-Weinberg.