Engineering Site for Islet Transplantation

DRI_Day Two_hi res_047 lowEngineering of ideal transplant sites for cell transplantation through the use of bioactive materials is a major focus of our laboratory, specifically the combination of biomaterials and active agents to generate a favorable site for islet or beta cell transplantation. Engineered biomaterial scaffolds, like the one shown above, can create optimal sites for housing islets. With a focus on enhancing oxygenation and vascularization, as well as local immunomodulation, to the engraftment site of islets, we have developed several platform technologies:

  1. Macro-porous scaffolds
  2. OxySite – Oxygen Generating Biomaterial
  3. Localized Drug Delivery
  4. Immunomodulatory Biomaterials

Efforts in this area are currently being supported by the JDRF by projects: “Engineered Bioactive Hydrogel Macrodevices for Islet Transplantation: Engineering an Optimal Site for Islet Transplantation”, a collaborative project with Drs Camillo Ricordi, Luca Inverardi, Rodolfo Alejandro, Alice Tomei, and Dora Berman-Weinberg.

“Development of an Extrahepatic Site for Beta Cell Replacement without Continuous, Systemic Immunosuppression”, a collaborative project with Dr. Andres Garcia