Engineering Site for Islet Transplantation
Engineering of ideal transplant sites for cell transplantation through the use of bioactive materials is a major focus of our laboratory, specifically the combination of biomaterials and active agents to generate a favorable site for islet or beta cell transplantation. Engineered biomaterial scaffolds, like the one shown above, can create optimal sites for housing islets. With a focus on enhancing oxygenation and vascularization, as well as local immunomodulation, to the engraftment site of islets, we have developed several platform technologies:
- Macro-porous scaffolds
- OxySite – Oxygen Generating Biomaterial
- Localized Drug Delivery
- Immunomodulatory Biomaterials
Efforts in this area are currently being supported by the JDRF by projects: “Engineered Bioactive Hydrogel Macrodevices for Islet Transplantation: Engineering an Optimal Site for Islet Transplantation”, a collaborative project with Drs Camillo Ricordi, Luca Inverardi, Rodolfo Alejandro, Alice Tomei, and Dora Berman-Weinberg.
“Development of an Extrahepatic Site for Beta Cell Replacement without Continuous, Systemic Immunosuppression”, a collaborative project with Dr. Andres Garcia