UF BME Professor Huabei Jiang has written a new book on Diffuse Optical Tomography. Dr. Jiang’s insights into the physics and applications of this cutting edge technology are captured in this text, which promises to be both a reference for researchers in the field and students learning how to understand and apply the approach to biomedical problems.
From the Book Cover:
Written by an authority involved in the field since its nascent stages, Diffuse Optical Tomography: Principles and Applications is a long-awaited profile of a revolutionary imaging method. Diffuse optical tomography (DOT) provides spatial distributions of intrinsic tissue optical properties or molecular contrast agents through model-based reconstruction algorithms using near-infrared (NIR) measurements along or near the boundary of tissue.
Despite the practical value of DOT, many engineers from electrical or applied mathematics backgrounds do not have a sufficient understanding of its vast clinical applications and portability value, or its uncommon advantages as a tool for obtaining functional, cellular, and molecular parameters. A collection of the author’s research and experience, this book fuses historical perspective and experiential anecdotes with fundamental principles and vital technical information needed to successfully apply this technology—particularly in medical imaging.
This reference finally outlines how to implement DOT to create experimental image systems and adapt the results of laboratory studies for use in clinical applications including:
- Early-stage detection of breast tumors and prostate cancer
- “Real-time” functional brain imaging
- Joint imaging to treat progressive diseases such as arthritis
- Monitoring of tumor response
- New contrast mechanisms and multimodality methods
This book covers almost every aspect of DOT—including reconstruction algorithms based on nonlinear iterative Newton methods, instrumentation and calibration methods in both continuous-wave and frequency domains, and important issues in imaging contrast and spatial resolution. It also addresses phantom experiments and the development of various image-enhancing schemes and describes reconstruction methods based on contrast agents and fluorescence DOT. Offering a concise description of the particular problems involved in optical tomography, this reference explains DOT’s fundamental foundations and the principle of image reconstruction. It thoroughly explores computational methods, forward mathematical models, and inverse strategies, clearly illustrating solutions to key equations.