Gregory Hudalla, Ph.D.

Gregory Hudalla
Gregory Hudalla, Ph.D.
Assistant Professor & J. Crayton Pruitt Family Term Fellow
Primary Faculty
Peptide-based nanomaterials and immune therapies
1275 Center Drive, Biomedical Sciences Building J296, Gainesville, FL 32611
Office Phone: 
(352) 273-9326
Office Fax: 
(352) 273-9221
Home Page: 
B.S., Chemical Engineering, Illinois Institute of Technology, 2004
M.S., Biomedical Engineering, University of Wisconsin, 2006
Ph.D. Biomedical Engineering, University of Wisconsin, 2010
NIH NRSA Post-doctoral Fellow, Surgery, University of Chicago, 2013

Research Summary:

Dr. Hudalla’s research creates functional materials for therapeutic or diagnostic applications via molecular self-assembly. Hudalla develops synthetic peptides that can assemble into a desired nano-scale architecture, and then use these peptides as “tags” to organize biologically active molecules into functional materials. This creates glycosylated materials to modulate the activity of carbohydrate-binding proteins by attaching carbohydrates to peptides that self-assemble into elongated nanofibers. In another project, we create peptides that co-assemble into prescribed nanofibers or globular coiled-coils only upon mixing, which when expressed as recombinant fusions with functional proteins of interest, direct the self-assembly of different proteins into multi-functional nanomaterials. Hudalla's long-term goals are to create biomaterials that can modulate immune responses for treatment of autoimmune diseases, or create biomaterials that interfere with molecular-level events central to metastasis and viral infection.

Honors and Awards:

  • Early Career Award, University of Wisconsin-Madison, 2018
  • J. Crayton Pruitt Family Term Fellow, 2017-2020
  • Young Innovator by Cellular and Molecular Bioengineering, 2016
  • NSF CAREER Award, 2015
  • Faculty Teaching Excellence Award, University of Florida Department of Biomedical Engineering, 2015
  • National Science Foundation (NSF) Travel Award, Regenerative Medicine Workshop at Hilton Head, 2015
  • Outstanding Contribution, Cellular and Molecular Bioengineering Journal, 2015

Selected publications:

Google Scholar Citations Link

Restuccia, A.; Fettis, M.M.; Hudalla, G.A. “Glycomaterials for immunomodulation, immunotherapy, and infection prophylaxis.” Journal of Materials Chemistry B, 2016 doi:10.1039/C5TB01780G.

Restuccia, A.; Tian, Y.F.; Collier, J.H.; Hudalla, G.A. “Self-assembled glycopeptide nanofibers as modulators of galectin-1 bioactivity.” Cellular and Molecular Bioengineering, 2015, 8, 471-487.

Hudalla, G.A.; Sun, T.; Gasiorowski, J.Z.; Han, H.; Tian, Y.F.; Chong, A.S.; Collier, J.H. “Gradated assembly of multiple proteins into supramolecular nanomaterials.” Nature Materials, 2014, 13, 829-836.

Hudalla, G.A.; Modica, J.A.; Tian, Y.F.; Sun, T.; Rudra, J.S.; Chong, A.S. Mrksich, M.; Collier, J.H. “A self-adjuvanting supramolecular vaccine carrying a folded protein antigen.” Advanced Healthcare Materials, 2013, 2(8):1114-9.​