Kaiyuan Jiang, along with postdoctoral fellow Deborah Chaimov and graduate students Smit Patel, Jiapu Liang, Sydney Wiggins, and Magda Samojlik,and in collaboration with Dr. Cheslea Simmons’ lab at UF, recently published our findings on the fabrication of decellularized extracellular matrix (ECM) hydrogels for islet culture. This manuscript, published in the journal Biomaterials, evaluates the capacity of ECM hydrogels, isolated from bladder and pancreas, to support the long-term culture of both human and rodent islets. They also outline the dynamic interactions between islets, a multicellular organoid, and ECM, with the formation of 3D tubular structures over time. These findings outline the feasibility of using 3D hydrogels for islet culture, which can then be translated to improved islet-on-a-chip culture systems.
Congrats to Kaiyuan, Debbie, and the rest of the Stabler lab team!