Kaiyuan Jiang, along with Jessica Weaver (alumni of lab), Yangjunyi Li and Xiogjian Chen (MS students in lab), and Jiapu Liang (PhD student in lab), recently published their findings on the impact of local delivery of dexamethasone, a potent anti-inflammatory agent, on improving islet engraftment in the journal Biomaterials. Kaiyuan found that the local release of low-dose dexamethasone accelerated islet transplant efficiency. Examination of the local microenvironment found the local delivery of the drug increased the polarization of infiltrating macrophages from M1 to M2 (pro-engraftment). This platform will be further explored to examine its potential as a short-term adjuvant to support long-term acceptance of allograft transplants.
Congrats to Kaiyuan and team!!
Check out the article here: Local release of dexamethasone from macroporous scaffolds accelerates islet transplant engraftment by promotion of anti-inflammatory M2 macrophages