Hudalla Recieves 2018 Early Career Award
October 25, 2018
Congratulations to assistant professor, Dr. Gregory Hudalla, who received the 2018 Early Career Award from the University of Wisconsin-Madison College of Engineering.
Each year, the University of Wisconsin-Madison College of Engineering recognizes outstanding alumni during Engineers’ Day—a celebration of engineers.
Read more from his interview with the UW-Madison COE here.
Dr. Hudalla and Dr. Keselowsky Awarded $2.1 million NIH Grant to Manage Inflammation in Periodontal Disease
August 31, 2017
Dr. Benjamin Keselowsky (PI), professor, and Dr. Gregory Hudalla, assistant professor, along with collaborators, Shannon Wallet and Mark Wallet were recently awarded a $2.1 million NIH grant entitled “Tissue-Targeted Enzyme for Localized Tryptophan Catabolism to Direct Subcutaneous.”
Periodontal disease refers to the inflammatory processes that occur in the tissues surrounding the teeth in response to bacterial accumulations, or dental plaque, on the teeth. The chronic and progressive inflammation of the gums leads to bone destruction and loss of tissue attachment to the teeth.
The aim of this research is to develop a new approach of administering enzymes to locally shut down the inflammation associated with periodontal infection. Drs. Keselowsky and Hudalla have fused two proteins together to endow an enzyme which breaks down tryptophan and produces molecules called kynurenines, a powerful anti-inflammatory combination, with prolonged tissue retention capability using proteins that bind carbohydrates found in tissues.
Dr. Hudalla Receives the new Pruitt Family Endowed Faculty Fellowship
December 08, 2016
The J. Crayton Pruitt Family Department of Biomedical Engineering is proud to announce the awardees of the Pruitt Family Endowed Faculty Fellowships to recognize talented junior faculty!
- Dr. Kyle D. Allen, assistant professor and associate chair of undergraduate studies
- Dr. Aysegul Gunduz, assistant professor
- Dr. Gregory A. Hudalla, assistant professor
The Pruitt Family Endowed Faculty Fellowships was established this year through the generosity of Dr. J. Crayton Pruitt, Sr. Allen, Gunduz and Hudalla were awarded the fellowships during the department’s 5th Annual Pruitt Research Day. We hold Pruitt Research Day near the birth date Dr. J. Crayton Pruitt Sr. whose vision and generosity helped found the department.
Criteria for the selection was excellence in teaching and research, as evidenced by strong teaching evaluations in required as well as elective BME courses, research mentorship of BME PhD and BS students, prestigious external research recognitions including major publications, awards and/or grants. Appointment is for a one-time, three-year term.
Congratulations to Drs. Kyle D. Allen, Aysegul Gunduz and Gregory A. Hudalla!
Maggie & Wei’s research featured in J. Materials Chemistry B Hot Papers
February 21, 2016
Congratulations to Maggie Fettis, Yaohua Wei, Dr. Gregory Hudalla, et al. for co-authoring their article “Microgels with tunable affinity-controlled protein release via desolvation of self-assembled peptide nanofibers,” which was featured in the 2016 Journal of Materials Chemistry B Hot Papers.
With a growing number of bioactive protein drugs approved for clinical use each year, there is increasing need for vehicles for localized protein delivery to reduce administered doses, prevent off-target activity, and maintain protein bioactivity. Ideal protein delivery vehicles provide high encapsulation efficiency of bioactive drug, enable fine-tuning of protein release profiles, are biocompatible, and can be administered via minimally-invasive routes. Here we developed an approach to create micron-sized hydrated gels (i.e. “microgels”) for protein delivery that fulfill these requirements via desolvation of self-assembled β-sheet peptide nanofibers. The desolvating agent induced nanofiber physical crosslinking into microgels that retained β-sheet secondary structure and were stable in aqueous solutions. Biocompatible microgels formed via desolvation of self-assembled peptide nanofibers are therefore likely to be broadly useful as vehicles for localized delivery of bioactive proteins, as well as other therapeutic molecules.
The Journal of Materials Chemistry B is part of the Royal Society of Chemistry Publishing, focusing on the materials field. The journal is interdisciplinary, publishing work of international significance on all aspects of materials chemistry related to biology and medicine.