Hudalla Recieves 2019 BME Department Faculty Research Excellence Award
Congratulations Dr. Hudalla for winning the Faculty Research Excellence Award from the J. Crayton Pruitt Family Department of Biomedical Engineering!
Award winners were selected based on submitted nomination materials and faculty CVs/teaching evaluations.
Hudalla Receives R35 Award from the National Institute of General Medical Sciences
October 28, 2019
Gregory Hudalla, associate professor, J. Crayton Pruitt Family term fellow and university term professor, has received a Maximizing Investigators’ Research Award (R35) from the National Institute of General Medical Sciences (NIGMS). NIGMS is a division of the National Institutes of Health (NIH). The $1.8M grant will fund Hudalla’s study of “Glycosylation as a Structural Determinant in Peptide Fibrillization” over the next five years.
Carbohydrates are extraordinarily abundant in the natural world. They make up cellulose in trees and chitin in sea creatures’ exoskeletons. They also decorate all human cells and nearly half of all human proteins, which helps our immune system identify foreign invaders. Yet, “our understanding of the role of carbohydrates in health and disease lags far behind that of all other biomolecules,” said Hudalla, “due to a lack of sophisticated tools and techniques.” Through this award, his research program will close this knowledge gap by developing synthetic analogs of carbohydrate-modified proteins. Specifically, they will create carbohydrate-modified peptides that assemble into fibrillar (strand-like) architectures as a surrogate for highly complex folded proteins. Hudalla and his team will be looking at how carbohydrate appendages influence the folding of peptides into strand-like ‘nanofibers,’ as well as the way these nanofibers function in biological contexts.
Outcomes expected from this award:
- A diverse library of new carbohydrate-modified peptides
- Understanding of how carbohydrates alter the assembly and structure of peptide nanofibers
- New bio-inspired architectures built using peptides and carbohydrates
Hudalla leads the UF Laboratory for Supramolecular Biomaterials and Biotherapeutics, where researchers combine carbohydrates, peptides, and proteins into novel biomedical constructs. Their work provides fundamental insights into how these biomolecules interact with each other in various contexts. In turn, this knowledge enables researchers to predict and manipulate the structure and function of carbohydrates, peptides, and proteins within living systems.
Hudalla Recieves 2018 Early Career Award
October 25, 2018
Congratulations to assistant professor, Dr. Gregory Hudalla, who received the 2018 Early Career Award from the University of Wisconsin-Madison College of Engineering.
Each year, the University of Wisconsin-Madison College of Engineering recognizes outstanding alumni during Engineers’ Day—a celebration of engineers.
Read more from his interview with the UW-Madison COE here.
Hall, Hudalla, and Paravstu Receive $1 Million NSF RAISE Grant
August 29, 2017
Dr. Gregory A. Hudalla, assistant professor and J. Crayton Pruitt Family Term Fellow, and collaborators were recently awarded a $1 million NSF RAISE grant entitled, “RAISE: Design of co-assembling peptides as recombinant protein fusion tags for integrating enzymes into supramolecular hydrogels.”
The NSF Research Advanced by Interdisciplinary Science and Engineering (RAISE) program supports lines of research that promise transformational advances through prospective discoveries that reside at the interfaces of disciplinary boundaries and thus lie outside the scope of a single NSF program. This RAISE project is jointly funded by the Biological and Environmental Interactions of Nanoscale Materials program in CBET Division in the Engineering Directorate, the Molecular Biophysics Program in the Division of Molecular and Cellular Biosciences in the Biological Sciences Directorate, and the Office of Integrative Activities.
The multi-institutional team of Dr. Carol Hall, Camille Dreyfus Distinguished Professor at NC State University, Dr. Anant Paravastu, associate professor at Georgia Tech, and Dr. Hudalla, combine their expertise in computational modeling, biophysical characterization, and nuclear magnetic resonance to study peptide assembly into supramolecular (‘beyond the molecule’) structures. This RAISE award supports their on-going efforts to advance understanding of “peptide co-assembly” — the formation of a single supramolecular structure via interactions between two unique peptide molecules — as well as to use co-assembling peptides attached to proteins as a general strategy to create functional supramolecular biomaterials. The goals of this project are to establish a computational-experimental framework to uncover molecular-level design rules necessary to predict peptide co-assembly, and then to use these rules to develop novel enzyme-functionalized supramolecular biomaterials. This approach is anticipated to provide an extraordinary near-term improvement over the current state-of-the-art in enzyme immobilization methods, while also having a broader transformative impact on designing novel functional biomaterials for medical and technological applications.
Dr. Hudalla and Dr. Keselowsky Awarded $2.1 million NIH Grant to Manage Inflammation in Periodontal Disease
August 31, 2017
Dr. Benjamin Keselowsky (PI), professor, and Dr. Gregory Hudalla, assistant professor, along with collaborators, Shannon Wallet and Mark Wallet were recently awarded a $2.1 million NIH grant entitled “Tissue-Targeted Enzyme for Localized Tryptophan Catabolism to Direct Subcutaneous.”
Periodontal disease refers to the inflammatory processes that occur in the tissues surrounding the teeth in response to bacterial accumulations, or dental plaque, on the teeth. The chronic and progressive inflammation of the gums leads to bone destruction and loss of tissue attachment to the teeth.
The aim of this research is to develop a new approach of administering enzymes to locally shut down the inflammation associated with periodontal infection. Drs. Keselowsky and Hudalla have fused two proteins together to endow an enzyme which breaks down tryptophan and produces molecules called kynurenines, a powerful anti-inflammatory combination, with prolonged tissue retention capability using proteins that bind carbohydrates found in tissues.
Dr. Hudalla Receives the new Pruitt Family Endowed Faculty Fellowship
December 08, 2016
The J. Crayton Pruitt Family Department of Biomedical Engineering is proud to announce the awardees of the Pruitt Family Endowed Faculty Fellowships to recognize talented junior faculty!
- Dr. Kyle D. Allen, assistant professor and associate chair of undergraduate studies
- Dr. Aysegul Gunduz, assistant professor
- Dr. Gregory A. Hudalla, assistant professor
The Pruitt Family Endowed Faculty Fellowships was established this year through the generosity of Dr. J. Crayton Pruitt, Sr. Allen, Gunduz and Hudalla were awarded the fellowships during the department’s 5th Annual Pruitt Research Day. We hold Pruitt Research Day near the birth date Dr. J. Crayton Pruitt Sr. whose vision and generosity helped found the department.
Criteria for the selection was excellence in teaching and research, as evidenced by strong teaching evaluations in required as well as elective BME courses, research mentorship of BME PhD and BS students, prestigious external research recognitions including major publications, awards and/or grants. Appointment is for a one-time, three-year term.
Congratulations to Drs. Kyle D. Allen, Aysegul Gunduz and Gregory A. Hudalla!